Diet, Probiotics and Sleep - Who Influences Who?
Today we talk about probiotics, diet and the relationship between the biological clock it.
First of all, according to the usual first show our today's topic of the paper.
The topic main idea is Day-night variation of intestinal microorganisms and the effects of high-fat feeding on host physiological clock function and metabolism.
We all know that diet affects intestinal flora, and a fiber-rich, low-fat diet is more likely to allow probiotics to colonize the intestines than a high-calorie diet, but how does this flora affect the physiological clock?
To test this, the authors used rats with sterile intestines compared to normal rats with no special treatment.
In the first experiment, the authors confirmed that rats with sterile intestines were less susceptible to dietary differences in gene expression compared to rats with normal intestinal bacteria.This means that intestinal bacteria do interfere with gene expression, including sleep and metabolism.Then a high-fat diet reduced the performance of Bam1 and Clock, two genes involved in the regulation of the physiological clock.And this difference (compared to the low-fat group) occurred at night.This suggests that a high-fat diet reduces the sensitivity of genes in the host to the time cycle, and that this sensitivity contributes to the dysregulation of the physiological clock.
Next, the authors analyzed the feces and intestinal contents of high-fat diet and low-fat diet rats, and found that high-fat diet group had poorer bacterial abundance than low-fat diet group, and that there was no diurnal variation in the feces.In addition, the analysis of the contents showed that hydrogen sulfide in the high-fat group changed more significantly over time, whereas butyric acid in the low-fat diet group changed more significantly over time.The in vitro pattern of butyric acid in liver cells showed a cyclical change in the expression of cellular genes (especially the physiological clock component), but this was not the case for hydrogen sulfide.
So, a quick summary.
- Intestinal Bacteria Affects the Physiological Clock
- Diet interferes with intestinal flora
The evidence in this article is not direct enough, but it does suggest that insomniacs should consider diet and regulating intestinal flora.Otherwise, supplementation of specific nutrients alone will not regulate the physiological clock.
Check out our Sleep Supplement - Sommeil Good Night Probiotics for those with irregular sleep cycles.
